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The use of estrogens is considered by manufacturers and some authorities to be contraindicated in patients with active thrombotic or thromboembolic disorders.

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You should not take estradiol if you have abnormal vaginal bleeding, liver disease, breast or uterine cancer, hormone-dependent cancer, a recent history of heart attack or stroke, if you are pregnant, if you have ever had a blood clot (especially in your lung or your lower body), or if you are allergic to any medicines or food dyes.

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If you use low dose estradiol and progesterone for the same duration (25-27 days continuous) every month, uterine lining will not thicken and no bleeding will occur except some spotting at the beginning (see for a review).

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El Dr. Navid Mootabar, presidente de obstetricia y ginecologa en el Hospital de Northern Westchester en Mount Kisco, Nueva York, dijo que este estudio reafirma algunas de las evidencias anteriores que tenamos que sugeran que el consumo de marihuana no es seguro durante el embarazo.

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WARNING: CARDIOVASCULAR DISORDERS, BREAST CANCER, ENDOMETRIAL CANCER, AND PROBABLE DEMENTIA - Estrogen plus progestin therapy should not be used for the prevention of cardiovascular disease or dementia.

Postmarketing reports concerning a transdermal product (Climara) have included a few cases in which there were a combination of the symptoms of generalized hives or rash with swelling of the throat or eyelid edema.

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Postmarketing side effects with Vivelle-Dot include vaginal hemorrhage, abnormal withdrawal bleeding or flow, breakthrough bleeding, spotting, uterine leiomyomata, vaginitis, vaginal discharge, ovarian cancer and endometrial hyperplasia.

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